Synthesis of Substituted Chalcones and Investigation of Their Biological Activities
Suad A. Rashdan, Awatef M. Hassan, Qaher A. Mandeel, Noor M. Alasfoor, Zahra H. Dawood

The synthesis of highly antioxidants and antimicrobial agents has attracted great attention due to their high importance to human health. Chalcones are known to exhibit wide spectrum of biological activities such as anticancer, antibacterial and antioxidant. We synthesized chalcones C1-C7 by using aldol condensation of substituted aldehydes and substituted acetophenone under basic conditions. The antioxidant activity was investigated via DPPH method and the antibacterial activity was measured against four bacterial strain; two Gram (+) and two Gram (-) bacteria. Chalcone C1 showed the highest antioxidant activity with IC50 value of 0.364μmol/mL and C5 revealed the least antioxidant effect with IC50 value of 0.883μmol/mL. The antibacterial activity was tested for chalcones C1-C6 and the results revealed that Gram (+) bacteria are more susceptible to the tested chalcones than Gram (-) bacteria. Chalcones C5 and C6 showed the highest antibacterial activity against B. subtilis with inhibition zone of 18.33 ± 0.58 and 17.33 ± 0.58 mm, respectively. C4 also exhibited appreciable antibacterial effect against E. coli with 17.67 ± 1.53 mm inhibition zone. The inhibitory effect of Chalcones C1, C2 and C3 varied from as low as 10.67±0.58 mm to as high as 14.67±0.58 mm inhibition zone.

Full Text: PDF     DOI: 10.15640/jcb.v6n1a1